Tswelelopele High School was established in 1976 and was headed by Mr Monaisa L.A . The then learners were temporarily hosted at Ramatlakana middle school and only occupied their buildings in July 1976.
The school was donated to the then Bophuthatswana self Governing Territory by the Western Transvaal Administration Board and officially opened by the minister of Education Mr Setlogelo and the circuit manager Mr P.P Phaladi
Since its creation the school had its ups and downs with regards the matriculation results.
This was mainly attributed to the many changes in the principalship of the school.
Among the former principals of the school, there are Mr Ntsimane, Mr S. Ramantsi, Ms J Parker, Mr Lekete, Mr Moleoka, Mr Diphoko and around 1985 some stability was brought by Mr S Motsepe who handed the reigns to his then Deputy Principal Mr L.W Mogokoyane.